8U6L

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(2-(5-chloro-2-((6-cyanonaphthalen-1-yl)oxy)phenoxy)ethyl)-N-methylacrylamide (JLJ748), a non-nucleoside inhibitor

Summary for 8U6L

Entry DOI	10.2210/pdb8u6l/pdb
Descriptor	Reverse transcriptase/ribonuclease H, p51 RT, N-(2-{5-chloro-2-[(6-cyanonaphthalen-1-yl)oxy]phenoxy}ethyl)-N-methylprop-2-enamide, ... (5 entities in total)
Functional Keywords	reverse transcriptase, antiviral, drug design, hiv-1, viral protein
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	2
Total formula weight	114508.50
Authors	Prucha, G.,Henry, S.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2023-09-13, release date: 2023-11-08)
Primary citation	Prucha, G.R.,Henry, S.,Hollander, K.,Carter, Z.J.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S. Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262:115894-115894, 2023 Cited by PubMed: 37883896 DOI: 10.1016/j.ejmech.2023.115894 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.486 Å)

Structure validation