8U69

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 3-chloro-5-(4-chloro-2-(2-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)benzonitrile (JLJ334), a non-nucleoside inhibitor

Summary for 8U69

• Entry DOI: 10.2210/pdb8u69/pdb
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, 3-chloro-5-{4-chloro-2-[2-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}benzonitrile, ... (4 entities in total)
• Functional Keywords: reverse transcriptase, antiviral, drug design, hiv-1, viral protein
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 2
• Total formula weight: 114481.40

Authors

Hollander, K.,Carter, Z.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2023-09-13, release date: 2023-11-08)

• Primary citation: Prucha, G.R.,Henry, S.,Hollander, K.,Carter, Z.J.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S.; Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase.; Eur.J.Med.Chem., 262:115894-115894, 2023; PubMed: 37883896; DOI: 10.1016/j.ejmech.2023.115894

Experimental method

X-RAY DIFFRACTION (2.45 Å)