8U48
Crystal structure of Bacteroides thetaiotamicron BT1285 D161A-E163A inactive Endoglycosidase in complex with high-mannose N-glycan (Man9GlcNAc2) substrate
Summary for 8U48
Entry DOI | 10.2210/pdb8u48/pdb |
Descriptor | Endo-beta-N-acetylglucosaminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | inactive endoglycosidase, artificial lectin, high-mannose specific, bacteroides, gh18 family, carbohydrate |
Biological source | Bacteroides thetaiotaomicron VPI-5482 |
Total number of polymer chains | 2 |
Total formula weight | 64854.31 |
Authors | Sastre, D.E.,Sultana, N.,Navarro, M.V.A.S.,Sundberg, E.J. (deposition date: 2023-09-09, release date: 2024-05-29, Last modification date: 2024-06-26) |
Primary citation | Sastre, D.E.,Sultana, N.,V A S Navarro, M.,Huliciak, M.,Du, J.,Cifuente, J.O.,Flowers, M.,Liu, X.,Lollar, P.,Trastoy, B.,Guerin, M.E.,Sundberg, E.J. Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate. Nat Commun, 15:5123-5123, 2024 Cited by PubMed: 38879612DOI: 10.1038/s41467-024-48802-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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