8U48

Crystal structure of Bacteroides thetaiotamicron BT1285 D161A-E163A inactive Endoglycosidase in complex with high-mannose N-glycan (Man9GlcNAc2) substrate

8U48 の概要

• エントリーDOI: 10.2210/pdb8u48/pdb
• 分子名称: Endo-beta-N-acetylglucosaminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: inactive endoglycosidase, artificial lectin, high-mannose specific, bacteroides, gh18 family, carbohydrate
• 由来する生物種: Bacteroides thetaiotaomicron VPI-5482
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64854.31

構造登録者

Sastre, D.E.,Sultana, N.,Navarro, M.V.A.S.,Sundberg, E.J. (登録日: 2023-09-09, 公開日: 2024-05-29, 最終更新日: 2024-06-26)

• 主引用文献: Sastre, D.E.,Sultana, N.,V A S Navarro, M.,Huliciak, M.,Du, J.,Cifuente, J.O.,Flowers, M.,Liu, X.,Lollar, P.,Trastoy, B.,Guerin, M.E.,Sundberg, E.J.; Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate.; Nat Commun, 15:5123-5123, 2024; PubMed: 38879612; DOI: 10.1038/s41467-024-48802-3

実験手法

X-RAY DIFFRACTION (1.9 Å)