8U02

CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant and dopamine

8U02 の概要

• エントリーDOI: 10.2210/pdb8u02/pdb
• EMDBエントリー: 41766 41776
• 分子名称: D(2) dopamine receptor, Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
• 機能のキーワード: gpcr, dopamine, drd2, dominant negative, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 138218.20

構造登録者

Krumm, B.E.,Kapolka, N.J.,Fay, J.F.,Roth, B.L. (登録日: 2023-08-28, 公開日: 2024-08-21)

• 主引用文献: Knight, K.M.,Krumm, B.E.,Kapolka, N.J.,Ludlam, W.G.,Cui, M.,Mani, S.,Prytkova, I.,Obarow, E.G.,Lefevre, T.J.,Wei, W.,Ma, N.,Huang, X.P.,Fay, J.F.,Vaidehi, N.,Smrcka, A.V.,Slesinger, P.A.,Logothetis, D.E.,Martemyanov, K.A.,Roth, B.L.,Dohlman, H.G.; A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.; Nat Commun, 15:6643-6643, 2024; PubMed: 39103320; DOI: 10.1038/s41467-024-50964-z

実験手法

ELECTRON MICROSCOPY (3.28 Å)