8TZB

Structure of the C-terminal half of LRRK2 bound to GZD-824 (I2020T mutant)

8TZB の概要

• エントリーDOI: 10.2210/pdb8tzb/pdb
• EMDBエントリー: 41753
• 分子名称: Leucine-rich repeat serine/threonine-protein kinase 2, designed ankyrin repeat proteins E11, 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide (3 entities in total)
• 機能のキーワード: kinase inhibitors, kinase, gtpases, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 306762.25

構造登録者

Villagran-Suarez, A.,Sanz-Murillo, M.,Alegrio-Louro, J.,Leschziner, A. (登録日: 2023-08-26, 公開日: 2023-12-06, 最終更新日: 2023-12-27)

• 主引用文献: Sanz Murillo, M.,Villagran Suarez, A.,Dederer, V.,Chatterjee, D.,Alegrio Louro, J.,Knapp, S.,Mathea, S.,Leschziner, A.E.; Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.; Sci Adv, 9:eadk6191-eadk6191, 2023; PubMed: 38039358; DOI: 10.1126/sciadv.adk6191

実験手法

ELECTRON MICROSCOPY (3.1 Å)