8TYP

Complement Protease C1s Inhibited by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide

8TYP の概要

• エントリーDOI: 10.2210/pdb8typ/pdb
• 分子名称: Complement C1s subcomponent, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide, ... (4 entities in total)
• 機能のキーワード: complement, protease, inhibitor, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39037.83

構造登録者

Geisbrecht, B.V. (登録日: 2023-08-25, 公開日: 2023-11-29, 最終更新日: 2024-02-14)

• 主引用文献: Xu, X.,Herdendorf, T.J.,Duan, H.,Rohlik, D.L.,Roy, S.,Zhou, H.,Alkhateeb, H.,Khandelwal, S.,Zhou, Q.,Li, P.,Arepally, G.M.,Walker, J.K.,Garcia, B.L.,Geisbrecht, B.V.; Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs.; J Immunol., 212:689-701, 2024; PubMed: 38149922; DOI: 10.4049/jimmunol.2300630

実験手法

X-RAY DIFFRACTION (1.8 Å)