8TVT

Structure of human Cysteine desulfurase Nfs1 with L-propargylglycine bound to active site PLP in complex with ISD11, Acp1 and ISCU2

Summary for 8TVT

• Entry DOI: 10.2210/pdb8tvt/pdb
• Descriptor: Cysteine desulfurase, TETRAETHYLENE GLYCOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... (18 entities in total)
• Functional Keywords: nfs1, pg-plp bound, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 84137.02

Authors

Cygler, M.,Boniecki, M.T. (deposition date: 2023-08-18, release date: 2024-09-11)

• Primary citation: Zangari, J.,Stehling, O.,Freibert, S.A.,Rouaud, F.,Maundrell, K.,Beinier, V.S.,Ferre, M.S.,Vartholomaiou, E.,Montessuit, S.,Schulz, V.,Zuhra, K.,Ruiz, V.G.,Rudaz, S.,Szabo, C.,Hanschke, S.,Tsukamoto, T.,Boniecki, M.T.,Cygler, M.,Lill, R.,Martinou, J.C.; D-Cysteine impairs tumor growth by inhibiting cysteine desulfurase NFS1; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)