8TR3

Cryo-EM structure of HmAb64 scFv in complex with CNE40 SOSIP trimer

8TR3 の概要

• エントリーDOI: 10.2210/pdb8tr3/pdb
• EMDBエントリー: 41569
• 分子名称: CNE40 SOSIP Envelope glycoprotein gp120, CNE40 SOSIP Transmembrane protein gp41, HmAb64 Fv heavy chain, ... (6 entities in total)
• 機能のキーワード: hiv, env, glycoprotein, mab, immune system, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 301983.21

構造登録者

Chan, K.-W.,Kong, X.P. (登録日: 2023-08-09, 公開日: 2024-06-19)

• 主引用文献: Wang, S.,Chan, K.W.,Wei, D.,Ma, X.,Liu, S.,Hu, G.,Park, S.,Pan, R.,Gu, Y.,Nazzari, A.F.,Olia, A.S.,Xu, K.,Lin, B.C.,Louder, M.K.,McKee, K.,Doria-Rose, N.A.,Montefiori, D.,Seaman, M.S.,Zhou, T.,Kwong, P.D.,Arthos, J.,Kong, X.P.,Lu, S.; Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains.; Nat Commun, 15:4301-4301, 2024; PubMed: 38773089; DOI: 10.1038/s41467-024-48514-8

実験手法

ELECTRON MICROSCOPY (3.74 Å)