8TR1

Crystal structure of trypanosome brucei hypoxanthine guanine phosphopribosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2- phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine

8TR1 の概要

• エントリーDOI: 10.2210/pdb8tr1/pdb
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid (3 entities in total)
• 機能のキーワード: inhibitor, complex, purine base, transferase
• 由来する生物種: Trypanosoma brucei
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 91660.42

構造登録者

Guddat, L.W. (登録日: 2023-08-09, 公開日: 2024-05-08, 最終更新日: 2024-05-22)

• 主引用文献: Keough, D.T.,Petrova, M.,King, G.,Kratochvil, M.,Pohl, R.,Dolezelova, E.,Zikova, A.,Guddat, L.W.,Rejman, D.; Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.; J.Med.Chem., 67:7158-7175, 2024; PubMed: 38651522; DOI: 10.1021/acs.jmedchem.4c00021

実験手法

X-RAY DIFFRACTION (2.46 Å)