8TPX
Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: trans-oriented 1B2 and ACP
Summary for 8TPX
| Entry DOI | 10.2210/pdb8tpx/pdb |
| EMDB information | 41495 41496 |
| Descriptor | EryAII,EryAII,EryAII,6-deoxyerythronolide-B synthase EryA3, modules 5 and 6, Antibody Fragment 1B2, Heavy Chain, Antibody Fragment 1B2, Light Chain (3 entities in total) |
| Functional Keywords | polyketide synthase, antibody, biosynthetic protein |
| Biological source | Saccharopolyspora erythraea More |
| Total number of polymer chains | 5 |
| Total formula weight | 611632.18 |
| Authors | Cogan, D.P.,Soohoo, A.M.,Chen, M.,Brodsky, K.L.,Liu, Y.,Khosla, C. (deposition date: 2023-08-05, release date: 2024-08-07, Last modification date: 2024-09-04) |
| Primary citation | Cogan, D.P.,Soohoo, A.M.,Chen, M.,Liu, Y.,Brodsky, K.L.,Khosla, C. Structural basis for intermodular communication in assembly-line polyketide biosynthesis. Nat.Chem.Biol., 2024 Cited by PubMed: 39179672DOI: 10.1038/s41589-024-01709-y PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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