8TM7
Human NAMPT in complex with substrate NAM and small molecule activator NP-A3
Summary for 8TM7
Entry DOI | 10.2210/pdb8tm7/pdb |
Descriptor | Nicotinamide phosphoribosyltransferase, GLYCEROL, NICOTINAMIDE, ... (7 entities in total) |
Functional Keywords | nad+ aging enzyme activation, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 114883.99 |
Authors | |
Primary citation | Gordon-Blake, J.,Ratia, K.,Weidig, V.,Velma, G.R.,Ackerman-Berrier, M.,Penton, C.,Musku, S.R.,Alves, E.T.M.,Driver, T.,Tai, L.,Thatcher, G.R.J. Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. Acs Med.Chem.Lett., 15:205-214, 2024 Cited by PubMed: 38352833DOI: 10.1021/acsmedchemlett.3c00391 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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