8TM7

Human NAMPT in complex with substrate NAM and small molecule activator NP-A3

Summary for 8TM7

• Entry DOI: 10.2210/pdb8tm7/pdb
• Descriptor: Nicotinamide phosphoribosyltransferase, GLYCEROL, NICOTINAMIDE, ... (7 entities in total)
• Functional Keywords: nad+ aging enzyme activation, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 114883.99

Authors

Ratia, K.M.,Thatcher, G.R. (deposition date: 2023-07-28, release date: 2024-06-12)

• Primary citation: Gordon-Blake, J.,Ratia, K.,Weidig, V.,Velma, G.R.,Ackerman-Berrier, M.,Penton, C.,Musku, S.R.,Alves, E.T.M.,Driver, T.,Tai, L.,Thatcher, G.R.J.; Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress.; Acs Med.Chem.Lett., 15:205-214, 2024; PubMed: 38352833; DOI: 10.1021/acsmedchemlett.3c00391

Experimental method

X-RAY DIFFRACTION (1.79 Å)