8TLR

Crystal Structure of human HRAS G12C covalently bound to AMG 510

Summary for 8TLR

• Entry DOI: 10.2210/pdb8tlr/pdb
• Descriptor: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, AMG 510 (bound form), ... (5 entities in total)
• Functional Keywords: hras, h-ras, sotorasib, ras, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 19951.40

Authors

Morstein, J.,Guiley, K.Z.,Shokat, K.M. (deposition date: 2023-07-27, release date: 2024-07-31)

• Primary citation: Morstein, J.,Yang, Y.,Fernando, M.,Zhu, L.,Bowcut, V.,Jenkins, M.L.,Evans, J.T.,Guiley, K.Z.,Peacock, D.M.,Burke, J.E.,Lightstone, F.C.,Shokat, K.M.; Targeting Ras-, Rho-, and Rab-Family GTPases via a Conserved Cryptic Pocket; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.70003947485 Å)