8TI4

monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface

Summary for 8TI4

• Entry DOI: 10.2210/pdb8ti4/pdb
• Descriptor: IgG1 Fab heavy chain, mutated to promote correct pairing, IgG1 Fab light chain, mutated for better pairing with cognate heavy chain, GLYCEROL, ... (4 entities in total)
• Functional Keywords: igg1 antigen binding fragment, mutated, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 47050.46

Authors

Oganesyan, V.Y.,van Dyk, N.,Mazor, Y. (deposition date: 2023-07-19, release date: 2023-11-22)

• Primary citation: Bagert, J.D.,Oganesyan, V.,Chiang, C.I.,Iannotti, M.,Lin, J.,Yang, C.,Payne, S.,McMahon, W.,Edwards, S.,Dippel, A.,Hutchinson, M.,Huang, F.,Aleti, V.,Niu, C.,Qian, C.,Denham, J.,Ferreira, S.,Pradhan, P.,Penney, M.,Wang, C.,Liu, W.,Walseng, E.,Mazor, Y.; Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C H 1-C lambda interface.; Mabs, 15:2273449-2273449, 2023; PubMed: 37930310; DOI: 10.1080/19420862.2023.2273449

Experimental method

X-RAY DIFFRACTION (2.1 Å)