8THR

Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an occluded conformation

8THR の概要

• エントリーDOI: 10.2210/pdb8thr/pdb
• EMDBエントリー: 41269
• 分子名称: fluorescent protein mVenus,Synaptic vesicular amine transporter,GFP nano body,Synaptic vesicular amine transporter,Synaptic vesicular amine transporter, (3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one (2 entities in total)
• 機能のキーワード: monoamine, neurotransmitter, synaptic vesicles, major facilitator superfamily, slc18, transport protein
• 由来する生物種: Aequorea victoria; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 94168.35

構造登録者

Dalton, M.P.,Coleman, J.A. (登録日: 2023-07-17, 公開日: 2023-10-25, 最終更新日: 2024-05-08)

• 主引用文献: Dalton, M.P.,Cheng, M.H.,Bahar, I.,Coleman, J.A.; Structural mechanisms for VMAT2 inhibition by tetrabenazine.; Elife, 12:-, 2024; PubMed: 38517752; DOI: 10.7554/eLife.91973

実験手法

ELECTRON MICROSCOPY (3.12 Å)