8TGS

The crystal structure of the post-reactive state of UDP-sugar pyrophosphorylase from Leishmania major in complex with product UDP-Glucose and by-product analog VO4 (orthovanadate)

Summary for 8TGS

• Entry DOI: 10.2210/pdb8tgs/pdb
• Descriptor: UTP-monosaccharide-1-phosphate uridylyltransferase, URIDINE-5'-DIPHOSPHATE-GLUCOSE, VANADATE ION, ... (5 entities in total)
• Functional Keywords: carbohydrate biosynthesis, nucleotidyltransferase, catalysis, molecular mechanism, sugar binding protein
• Biological source: Leishmania major
• Total number of polymer chains: 1
• Total formula weight: 67641.43

Authors

Prakash, O.,Fuehring, J.I.,Baruch, P.,Routier, F.H.,Fedorov, R. (deposition date: 2023-07-13, release date: 2025-01-22)

• Primary citation: Prakash, O.,Fuehring, J.I.,Baruch, P.,Routier, F.H.,Fedorov, R.; The post-reactive state structures of Leishmania major UDP-sugar pyrophosphorylase provide insights into the product release mechanism; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)