8TFQ
Fab from C10-S66K antibody in complex with fentanyl
Summary for 8TFQ
Entry DOI | 10.2210/pdb8tfq/pdb |
Descriptor | Light chain from Fab of C10_S66K antibody, Heavy chain from Fab of C10_S66K antibody, N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide, ... (4 entities in total) |
Functional Keywords | antibody, fentanyl, opioid., immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 94133.41 |
Authors | Pholcharee, T.,Wilson, I.A. (deposition date: 2023-07-11, release date: 2023-08-16, Last modification date: 2023-08-23) |
Primary citation | Eubanks, L.M.,Pholcharee, T.,Oyen, D.,Natori, Y.,Zhou, B.,Wilson, I.A.,Janda, K.D. An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression. Acs Chem Neurosci, 14:2849-2856, 2023 Cited by PubMed: 37534714DOI: 10.1021/acschemneuro.3c00455 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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