8TBU
Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator Compound 12
Summary for 8TBU
Entry DOI | 10.2210/pdb8tbu/pdb |
Descriptor | Pyruvate kinase PKLR, 6-[(4-hydroxyphenyl)methyl]-2,4-dimethyl-4,6-dihydro-5H-[1,3]thiazolo[5',4':4,5]pyrrolo[2,3-d]pyridazin-5-one, PYRUVIC ACID, ... (7 entities in total) |
Functional Keywords | erythrocyte pyruvate kinase, pkr, pklr, allosteric activator, glycolysis, transferase, transferase-activator complex, transferase/activator |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 8 |
Total formula weight | 474393.90 |
Authors | Jin, L.,Padyana, A. (deposition date: 2023-06-29, release date: 2023-12-27, Last modification date: 2024-03-20) |
Primary citation | Liu, T.,Padyana, A.K.,Judd, E.T.,Jin, L.,Hammoudeh, D.,Kung, C.,Dang, L. Structure-Based Design of AG-946, a Pyruvate Kinase Activator. Chemmedchem, 19:e202300559-e202300559, 2024 Cited by PubMed: 38109501DOI: 10.1002/cmdc.202300559 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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