8TBB

F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3

8TBB の概要

• エントリーDOI: 10.2210/pdb8tbb/pdb
• 分子名称: T-cell immunoglobulin mucin receptor 3, F9S Fab heavy chain, F9S Fab light chain, ... (5 entities in total)
• 機能のキーワード: fab, igv domain of tim-3, complex, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 60055.29

構造登録者

Oganesyan, V.,van Dyk, N.,Mazor, Y.,Yang, C. (登録日: 2023-06-28, 公開日: 2024-08-28)

• 主引用文献: Clancy-Thompson, E.,Perry, T.,Pryts, S.,Jaiswal, A.,Oganesyan, V.,van Dyk, N.,Yang, C.,Garcia, A.,Yu, W.,Moynihan, J.,Miller, C.,Mulgrew, K.,Cobbold, M.,Mazor, Y.,Hammond, S.,Pollizzi, K.; Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3; To be published,

実験手法

X-RAY DIFFRACTION (2.5 Å)