8TB8
Sequence specific (AATT) orientation of Hoechst molecules at a unique minor groove binding site (position1) within a self-assembled 3D DNA lattice (4x5)
Summary for 8TB8
Entry DOI | 10.2210/pdb8tb8/pdb |
Descriptor | DNA (5'-D(*GP*AP*CP*AP*AP*TP*TP*GP*CP*TP*GP*AP*CP*GP*AP*CP*AP*CP*TP*CP*A*(HT1))-3'), DNA (5'-D(P*CP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*GP*TP*GP*T)-3'), ... (7 entities in total) |
Functional Keywords | self-assembly, dna nanotechnology, dna scaffold, crystal lattice, dna, minor groove binders, netropsin, dapi, hoechst, impypy, polyamide, host-guest |
Biological source | synthetic construct More |
Total number of polymer chains | 4 |
Total formula weight | 13272.30 |
Authors | Simmons, C.R.,MacCulloch, T.,Stephanopoulos, N.,Yan, H. (deposition date: 2023-06-28, release date: 2023-12-20) |
Primary citation | Simmons, C.R.,Buchberger, A.,Henry, S.J.W.,Novacek, A.,Fahmi, N.E.,MacCulloch, T.,Stephanopoulos, N.,Yan, H. Site-Specific Arrangement and Structure Determination of Minor Groove Binding Molecules in Self-Assembled Three-Dimensional DNA Crystals. J.Am.Chem.Soc., 145:26075-26085, 2023 Cited by PubMed: 37987645DOI: 10.1021/jacs.3c07802 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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