8TA8

Sequence specific (AATT) orientation of netropsin molecules at two unique minor groove binding sites within a self-assembled 3D DNA lattice (4x6)

Summary for 8TA8

• Entry DOI: 10.2210/pdb8ta8/pdb
• Descriptor: DNA (5'-D(*GP*AP*GP*AP*AP*TP*TP*CP*CP*TP*GP*AP*CP*GP*GP*AP*AP*AP*TP*TP*A*(NT)*(NT))-3'), DNA (5'-D(P*CP*CP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*TP*T)-3'), ... (6 entities in total)
• Functional Keywords: self-assembly, dna nanotechnology, dna scaffold, crystal lattice, dna, minor groove binders, netropsin, dapi, hoechst, impypy, polyamide, host-guest
• Biological source: synthetic construct; More
• Total number of polymer chains: 4
• Total formula weight: 13654.39

Authors

Simmons, C.R.,MacCulloch, T.,Stephanopoulos, N.,Yan, H. (deposition date: 2023-06-26, release date: 2023-12-20)

• Primary citation: Simmons, C.R.,Buchberger, A.,Henry, S.J.W.,Novacek, A.,Fahmi, N.E.,MacCulloch, T.,Stephanopoulos, N.,Yan, H.; Site-Specific Arrangement and Structure Determination of Minor Groove Binding Molecules in Self-Assembled Three-Dimensional DNA Crystals.; J.Am.Chem.Soc., 145:26075-26085, 2023; PubMed: 37987645; DOI: 10.1021/jacs.3c07802

Experimental method

X-RAY DIFFRACTION (3.05 Å)