8T6M

Human leukocyte antigen bound by two alloreactive antibody Fabs

Summary for 8T6M

• Entry DOI: 10.2210/pdb8t6m/pdb
• EMDB information: 41072
• Descriptor: JTK191b_M07_Light, JTK191b_M07_Fab, JTK191b_L02_Light, ... (7 entities in total)
• Functional Keywords: antibody, human leukocyte antigen, graft rejection, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 7
• Total formula weight: 128859.51

Authors

Kizziah, J.L.,Killian, J.T.,Diaz-Avalos, R.,Qiu, S.,Yang, G.,Green, T.,Lund, F.E. (deposition date: 2023-06-16, release date: 2024-12-25, Last modification date: 2025-07-09)

• Primary citation: Killian, J.T.,King, R.G.,Kizziah, J.L.,Fucile, C.F.,Diaz-Avalos, R.,Qiu, S.,Silva-Sanchez, A.,Mousseau, B.J.,Macon, K.J.,Callahan, A.R.,Yang, G.,Hossain, M.E.,Akther, J.,Houp, J.A.,Rosenblum, F.D.,Porrett, P.M.,Ong, S.C.,Kumar, V.,Mobley, J.A.,Saphire, E.O.,Kearney, J.F.,Randall, T.D.,Rosenberg, A.F.,Green, T.J.,Lund, F.E.; Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.14 Å)