8T6F
Crystal structure of human MBP-Myeloid cell leukemia 1 (Mcl-1) in complex with BRD810 inhibitor
Summary for 8T6F
| Entry DOI | 10.2210/pdb8t6f/pdb |
| Descriptor | Maltose/maltodextrin-binding periplasmic protein/Induced myeloid leukemia cell differentiation protein Mcl-1 Chimera, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, MAGNESIUM ION, ... (7 entities in total) |
| Functional Keywords | inhibitor, mcl1, mbp-fusion, brd810, apoptosis |
| Biological source | Escherichia coli K-12 More |
| Total number of polymer chains | 1 |
| Total formula weight | 58609.03 |
| Authors | |
| Primary citation | Rauh, U.,Wei, G.,Serrano-Wu, M.,Kosmidis, G.,Kaulfuss, S.,Siegel, F.,Thede, K.,McFarland, J.,Poncet-Montange, G.,Lemke, T.L.,Werbeck, N.,Nowak-Reppel, K.,Pilari, S.,Menz, S.,Ocker, M.,Kaushik, V.,Hubbard, B.,Ziegelbauer, K.,Golub, T.R. BRD810 is a novel highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models to be published, |
| Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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