8T5W

Influenza PAN endonuclease I38T mutant with Baloxavir

8T5W の概要

• エントリーDOI: 10.2210/pdb8t5w/pdb
• 分子名称: Polymerase acidic protein, MANGANESE (II) ION, Baloxavir acid, ... (4 entities in total)
• 機能のキーワード: influenza endonuclease, resistance, drug discovery, metal-binding pharmacophore, antiviral protein, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Influenza A virus (A/California/04/2009(H1N1))
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23489.34

構造登録者

Kohlbrand, A.J.,Cohen, S.M. (登録日: 2023-06-14, 公開日: 2024-06-12)

• 主引用文献: Kohlbrand, A.J.,Stokes, R.W.,Sankaran, B.,Cohen, S.M.; Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants.; Biochemistry, 63:264-272, 2024; PubMed: 38190441; DOI: 10.1021/acs.biochem.3c00536

実験手法

X-RAY DIFFRACTION (1.65 Å)