8T5R
SOS2 crystal structure with fragment bound (compound 13)
Summary for 8T5R
Entry DOI | 10.2210/pdb8t5r/pdb |
Descriptor | Son of sevenless homolog 2, SULFATE ION, 4-(aminomethyl)benzene-1-sulfonamide, ... (4 entities in total) |
Functional Keywords | signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 57749.03 |
Authors | Gunn, R.J.,Lawson, J.D.,Ivetac, A.,Ulaganathan, T.,Coulombe, R.,Fethiere, J. (deposition date: 2023-06-14, release date: 2024-01-10, Last modification date: 2024-01-24) |
Primary citation | Smith, C.R.,Chen, D.,Christensen, J.G.,Coulombe, R.,Fethiere, J.,Gunn, R.J.,Hollander, J.,Jones, B.,Ketcham, J.M.,Khare, S.,Kuehler, J.,Lawson, J.D.,Marx, M.A.,Olson, P.,Pearson, K.E.,Ren, C.,Tsagris, D.,Ulaganathan, T.,Van't Veer, I.,Wang, X.,Ivetac, A. Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. J.Med.Chem., 67:774-781, 2024 Cited by PubMed: 38156904DOI: 10.1021/acs.jmedchem.3c02140 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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