8T5G

SOS2 co-crystal structure with fragment bound (compound 12)

Summary for 8T5G

Entry DOI	10.2210/pdb8t5g/pdb
Descriptor	Son of sevenless homolog 2, DIMETHYL SULFOXIDE, SULFATE ION, ... (5 entities in total)
Functional Keywords	signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	58031.33
Authors	Gunn, R.J.,Lawson, J.D.,Ivetac, A.,Ulaganathan, T.,Coulombe, R.,Fethiere, J. (deposition date: 2023-06-13, release date: 2024-01-10, Last modification date: 2024-01-24)
Primary citation	Smith, C.R.,Chen, D.,Christensen, J.G.,Coulombe, R.,Fethiere, J.,Gunn, R.J.,Hollander, J.,Jones, B.,Ketcham, J.M.,Khare, S.,Kuehler, J.,Lawson, J.D.,Marx, M.A.,Olson, P.,Pearson, K.E.,Ren, C.,Tsagris, D.,Ulaganathan, T.,Van't Veer, I.,Wang, X.,Ivetac, A. Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. J.Med.Chem., 67:774-781, 2024 Cited by PubMed: 38156904 DOI: 10.1021/acs.jmedchem.3c02140 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation