8T59

Crystal structure of Para.09 bound to TREM2

Summary for 8T59

Entry DOI	10.2210/pdb8t59/pdb
Descriptor	Para.09 heavy chain, Para.09 light chain, Triggering receptor expressed on myeloid cells 2, ... (7 entities in total)
Functional Keywords	antibody, fab, complex, antigen, peptide binding protein, immune system-peptide binding protein complex, immune system/peptide binding protein
Biological source	synthetic construct More
Total number of polymer chains	6
Total formula weight	101863.26
Authors	Wallweber, H.,Hsu, P.L. (deposition date: 2023-06-12, release date: 2024-07-31, Last modification date: 2024-10-09)
Primary citation	Hsiao, Y.C.,Wallweber, H.A.,Alberstein, R.G.,Lin, Z.,Du, C.,Etxeberria, A.,Aung, T.,Shang, Y.,Seshasayee, D.,Seeger, F.,Watkins, A.M.,Hansen, D.V.,Bohlen, C.J.,Hsu, P.L.,Hotzel, I. Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining. Nat Commun, 15:8382-8382, 2024 Cited by PubMed: 39333507 DOI: 10.1038/s41467-024-52442-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation