8T51

Crystal structure of Fab 3.10C2 bound to TREM2

8T51 の概要

• エントリーDOI: 10.2210/pdb8t51/pdb
• 分子名称: 3.10C2 Fab heavy chain, 3.10C2 Fab light chain, Triggering receptor expressed on myeloid cells 2 peptide, ... (9 entities in total)
• 機能のキーワード: antibody, fab, peptide binding protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 102728.02

構造登録者

Hsu, P.L.,Wallweber, H. (登録日: 2023-06-12, 公開日: 2024-06-19)

• 主引用文献: Hsiao, Y.,Lin, Z.,Du, C.,Echeverria, A.,Wallweber, H.A.,Aung, T.,Alberstein, R.G.,Shang, Y.,Seeger, F.,Watkins, A.,Seshasayee, D.,Hansen, D.V.,Bolen, C.,Hsu, P.L.,Hotzel, I.; Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining; To Be Published,

実験手法

X-RAY DIFFRACTION (1.9 Å)