8T2H

DYRK1A complex with DYR530

8T2H の概要

• エントリーDOI: 10.2210/pdb8t2h/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, (4P)-4-{(3M)-3-[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl}pyridin-2-amine, TETRAETHYLENE GLYCOL, ... (5 entities in total)
• 機能のキーワード: kinase, inhibitor, alzheimer's disease, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 86183.04

構造登録者

Montfort, W.R.,Basantes, L.E. (登録日: 2023-06-06, 公開日: 2024-05-15)

• 主引用文献: Montfort, W.R.,Basantes, L.E.; Discovery of DYR684, a Potent, Selective, Metabolically Stable, DYRK1A/B PROTAC utilizing a Novel Cereblon Molecular Glue; To Be Published,

実験手法

X-RAY DIFFRACTION (1.85 Å)