8T1F
Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047
Summary for 8T1F
Entry DOI | 10.2210/pdb8t1f/pdb |
Related | 8T1B 8T1C 8T1D 8T1E |
EMDB information | 40958 40959 40960 40961 40962 |
Descriptor | Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (3 entities in total) |
Functional Keywords | transient receptor potential v family member 4, trp, channel, trpv4, trp channels, membrane protein, antagonist, inhibited state, hc-067047 |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 515798.12 |
Authors | Talyzina, I.A.,Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-06-02, release date: 2023-07-05, Last modification date: 2024-06-19) |
Primary citation | Nadezhdin, K.D.,Talyzina, I.A.,Parthasarathy, A.,Neuberger, A.,Zhang, D.X.,Sobolevsky, A.I. Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14:3733-3733, 2023 Cited by PubMed: 37353478DOI: 10.1038/s41467-023-39346-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.49 Å) |
Structure validation
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