8T1F
Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | polymer | 1132 | 127717.9 | 4 | UniProt (Q9HBA0) UniProt (C5MKY7) Pfam (PF00023) Pfam (PF00520) In PDB | Homo sapiens (human) | TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC |
2 | A, B, C, D | 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide | non-polymer | 471.5 | 4 | Chemie (X7N) | |||
3 | A, B, C, D | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 4 | Chemie (POV) |
Sequence modifications
A, B, C, D: 1 - 871 (UniProt: Q9HBA0)
A, B, C, D: 882 - 1119 (UniProt: C5MKY7)
PDB | External Database | Details |
---|---|---|
Leu 872 | - | linker |
Val 873 | - | linker |
Pro 874 | - | linker |
Arg 875 | - | linker |
Gly 876 | - | linker |
Ser 877 | - | linker |
Ala 878 | - | linker |
Ala 879 | - | linker |
Ala 880 | - | linker |
Ala 881 | - | linker |
PDB | External Database | Details |
---|---|---|
Lys 1087 | Ala 207 | conflict |
Ser 1120 | - | expression tag |
Gly 1121 | - | expression tag |
Leu 1122 | - | expression tag |
Arg 1123 | - | expression tag |
Ser 1124 | - | expression tag |
Trp 1125 | - | expression tag |
Ser 1126 | - | expression tag |
His 1127 | - | expression tag |
Pro 1128 | - | expression tag |
Gln 1129 | - | expression tag |
Phe 1130 | - | expression tag |
Glu 1131 | - | expression tag |
Lys 1132 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 510871.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 4926.4 | |
All* | Total formula weight | 515798.1 |