8T1F

Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047

8T1F の概要

• エントリーDOI: 10.2210/pdb8t1f/pdb
• 関連するPDBエントリー: 8T1B 8T1C 8T1D 8T1E
• EMDBエントリー: 40958 40959 40960 40961 40962
• 分子名称: Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (3 entities in total)
• 機能のキーワード: transient receptor potential v family member 4, trp, channel, trpv4, trp channels, membrane protein, antagonist, inhibited state, hc-067047
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 515798.12

構造登録者

Talyzina, I.A.,Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (登録日: 2023-06-02, 公開日: 2023-07-05, 最終更新日: 2024-06-19)

• 主引用文献: Nadezhdin, K.D.,Talyzina, I.A.,Parthasarathy, A.,Neuberger, A.,Zhang, D.X.,Sobolevsky, A.I.; Structure of human TRPV4 in complex with GTPase RhoA.; Nat Commun, 14:3733-3733, 2023; PubMed: 37353478; DOI: 10.1038/s41467-023-39346-z

実験手法

ELECTRON MICROSCOPY (3.49 Å)