8T1D
Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD
Summary for 8T1D
Entry DOI | 10.2210/pdb8t1d/pdb |
Related | 8T1B 8T1C |
EMDB information | 40958 40959 40960 |
Descriptor | Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate (2 entities in total) |
Functional Keywords | transient receptor potential v family member 4, trp, channel, trpv4, trp channels, membrane protein, agonist, 4a-pdd, open state, 4alpha-phorbol 12, 13-didecanoate |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 513563.48 |
Authors | Talyzina, I.A.,Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-06-02, release date: 2023-07-05) |
Primary citation | Nadezhdin, K.D.,Talyzina, I.A.,Parthasarathy, A.,Neuberger, A.,Zhang, D.X.,Sobolevsky, A.I. Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14:3733-3733, 2023 Cited by PubMed: 37353478DOI: 10.1038/s41467-023-39346-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.35 Å) |
Structure validation
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