8SWS
Structure of K. lactis PNP S42E-H98R variant bound to transition state analog DADMe-IMMUCILLIN G and sulfate
Summary for 8SWS
Entry DOI | 10.2210/pdb8sws/pdb |
Related | 8SWP 8SWQ 8SWR 8SWT 8SWU |
Descriptor | Purine nucleoside phosphorylase, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, SULFATE ION, ... (4 entities in total) |
Functional Keywords | pentosyltransferase, purine nucleoside phosphorylase, transferase |
Biological source | Kluyveromyces lactis NRRL Y-1140 |
Total number of polymer chains | 6 |
Total formula weight | 203415.17 |
Authors | Fedorov, E.,Ghosh, A. (deposition date: 2023-05-19, release date: 2023-10-18, Last modification date: 2024-02-14) |
Primary citation | Minnow, Y.V.T.,Schramm, V.L.,Almo, S.C.,Ghosh, A. Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity. Biochemistry, 62:3116-3125, 2023 Cited by PubMed: 37812583DOI: 10.1021/acs.biochem.3c00264 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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