8SWS
Structure of K. lactis PNP S42E-H98R variant bound to transition state analog DADMe-IMMUCILLIN G and sulfate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Purine nucleoside phosphorylase | polymer | 307 | 33556.2 | 6 | UniProt (Q6CSZ6) Pfam (PF01048) | Kluyveromyces lactis NRRL Y-1140 | |
| 2 | G, J, M, P (A, B, D, E) | 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | non-polymer | 279.3 | 4 | Chemie (IM5) | |||
| 3 | H, I, K, L, N... (A, B, D, E, F) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 4 | U, V, W, X, Y... (A, B, C, D, E...) | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 306 (UniProt: Q6CSZ6)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Glu 42 | Ser 42 | engineered mutation |
| Arg 98 | His 98 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 201337.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2077.8 | |
| All* | Total formula weight | 203415.2 |
