8SWS

Structure of K. lactis PNP S42E-H98R variant bound to transition state analog DADMe-IMMUCILLIN G and sulfate

8SWS の概要

• エントリーDOI: 10.2210/pdb8sws/pdb
• 関連するPDBエントリー: 8SWP 8SWQ 8SWR 8SWT 8SWU
• 分子名称: Purine nucleoside phosphorylase, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: pentosyltransferase, purine nucleoside phosphorylase, transferase
• 由来する生物種: Kluyveromyces lactis NRRL Y-1140
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 203415.17

構造登録者

Fedorov, E.,Ghosh, A. (登録日: 2023-05-19, 公開日: 2023-10-18, 最終更新日: 2024-02-14)

• 主引用文献: Minnow, Y.V.T.,Schramm, V.L.,Almo, S.C.,Ghosh, A.; Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.; Biochemistry, 62:3116-3125, 2023; PubMed: 37812583; DOI: 10.1021/acs.biochem.3c00264

実験手法

X-RAY DIFFRACTION (1.99 Å)