8STP
Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) varient in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor
Summary for 8STP
Entry DOI | 10.2210/pdb8stp/pdb |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}indolizine-2-carbonitrile (3 entities in total) |
Functional Keywords | reverse transcriptase, antiviral, drug design, hiv-1, viral protein |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 2 |
Total formula weight | 114357.07 |
Authors | Hollander, K.,Frey, K.M.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2023-05-11, release date: 2023-11-29, Last modification date: 2023-12-13) |
Primary citation | Hollander, K.,Chan, A.H.,Frey, K.M.,Hunker, O.,Ippolito, J.A.,Spasov, K.A.,Yeh, Y.J.,Jorgensen, W.L.,Ho, Y.C.,Anderson, K.S. Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32:e4814-e4814, 2023 Cited by PubMed: 37861472DOI: 10.1002/pro.4814 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.09 Å) |
Structure validation
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