8STG
Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
8STG の概要
エントリーDOI | 10.2210/pdb8stg/pdb |
分子名称 | Fibroblast growth factor receptor 2, N-{4-[(5P)-4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}-2-methylpropanamide (2 entities in total) |
機能のキーワード | relay inhibitor, cytosolic protein, transferase-inhibitor complex, transferase/inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 73592.69 |
構造登録者 | |
主引用文献 | Subbiah, V.,Sahai, V.,Maglic, D.,Bruderek, K.,Toure, B.B.,Zhao, S.,Valverde, R.,O'Hearn, P.J.,Moustakas, D.T.,Schonherr, H.,Gerami-Moayed, N.,Taylor, A.M.,Hudson, B.M.,Houde, D.J.,Pal, D.,Foster, L.,Gunaydin, H.,Ayaz, P.,Sharon, D.A.,Goyal, L.,Schram, A.M.,Kamath, S.,Sherwin, C.A.,Schmidt-Kittler, O.,Jen, K.Y.,Ricard, F.,Wolf, B.B.,Shaw, D.E.,Bergstrom, D.A.,Watters, J.,Casaletto, J.B. RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations. Cancer Discov, 13:2012-2031, 2023 Cited by PubMed: 37270847DOI: 10.1158/2159-8290.CD-23-0475 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.79 Å) |
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