8STD

S127A variant of LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with authentic substrate NaAD and soaked with CS2

8STD の概要

• エントリーDOI: 10.2210/pdb8std/pdb
• 分子名称: Pyridinium-3,5-biscarboxylic acid mononucleotide synthase, MAGNESIUM ION, NICOTINIC ACID ADENINE DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: carboxylase, hydrolase, lyase (carbon-carbon), lyase
• 由来する生物種: Lactiplantibacillus plantarum WCFS1
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 163176.61

構造登録者

Chatterjee, S.,Rankin, J.A.,Hu, J.,Hausinger, R.P. (登録日: 2023-05-10, 公開日: 2023-12-27)

• 主引用文献: Chatterjee, S.,Nevarez, J.L.,Rankin, J.A.,Hu, J.,Hausinger, R.P.; Structure of the LarB-Substrate Complex and Identification of a Reaction Intermediate during Nickel-Pincer Nucleotide Cofactor Biosynthesis.; Biochemistry, 62:3096-3104, 2023; PubMed: 37831946; DOI: 10.1021/acs.biochem.3c00242

実験手法

X-RAY DIFFRACTION (2.65 Å)