8SS9

Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state)

8SS9 の概要

• エントリーDOI: 10.2210/pdb8ss9/pdb
• EMDBエントリー: 40741 40742 40743 40744 40745 40746 40747 40748 40749 40750
• 分子名称: Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid, ... (7 entities in total)
• 機能のキーワード: ampa receptor, neurotransmission, tarp gamma-5, perampanel, signaling protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 474788.97

構造登録者

Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Sobolevsky, A.I. (登録日: 2023-05-08, 公開日: 2023-09-06, 最終更新日: 2023-10-25)

• 主引用文献: Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Korman, A.,Jones, D.R.,Sobolevsky, A.I.; Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.; Nat.Struct.Mol.Biol., 30:1481-1494, 2023; PubMed: 37653241; DOI: 10.1038/s41594-023-01080-x

実験手法

ELECTRON MICROSCOPY (2.72 Å)