8SS0

Human sterol 14 alpha-demethylase (CYP51) in complex with the reaction intermediate 14 alpha-aldehyde dihydrolanosterol

8SS0 の概要

• エントリーDOI: 10.2210/pdb8ss0/pdb
• 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 3beta-hydroxy-10alpha,13alpha-lanosta-8,24-dien-30-al, ... (4 entities in total)
• 機能のキーワード: monooxygenase, cytochrome p450, cyp51, endoplasmic reticulum, sterol biosynthesis, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 106832.60

構造登録者

Hargrove, T.Y.,Wawrzak, Z.,Guengerich, F.P.,Lepesheva, G.I. (登録日: 2023-05-08, 公開日: 2024-01-17, 最終更新日: 2024-03-06)

• 主引用文献: McCarty, K.D.,Tateishi, Y.,Hargrove, T.Y.,Lepesheva, G.I.,Guengerich, F.P.; Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14 alpha-Demethylation.; Angew.Chem.Int.Ed.Engl., 63:e202317711-e202317711, 2024; PubMed: 38206808; DOI: 10.1002/anie.202317711

実験手法

X-RAY DIFFRACTION (2.25 Å)