8SR7

Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate

Summary for 8SR7

• Entry DOI: 10.2210/pdb8sr7/pdb
• EMDB information: 40721 40866 40875
• Descriptor: TRPM2 Chanzyme, 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ... (6 entities in total)
• Functional Keywords: trpm2 chanzyme, channel-enzyme, transport protein
• Biological source: Salpingoeca rosetta
• Total number of polymer chains: 4
• Total formula weight: 680372.29

Authors

Huang, Y.,Kumar, S.,Lu, W.,Du, J. (deposition date: 2023-05-05, release date: 2024-05-08, Last modification date: 2024-06-05)

• Primary citation: Huang, Y.,Kumar, S.,Lee, J.,Lu, W.,Du, J.; Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.; Nat.Struct.Mol.Biol., 2024; PubMed: 38773335; DOI: 10.1038/s41594-024-01316-4

Experimental method

ELECTRON MICROSCOPY (1.97 Å)