8SP8
Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)
Summary for 8SP8
Entry DOI | 10.2210/pdb8sp8/pdb |
EMDB information | 40676 |
Descriptor | Transient receptor potential cation channel subfamily V member 6, CHOLESTEROL HEMISUCCINATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ... (6 entities in total) |
Functional Keywords | phyto-cannabinoid, phytocannabinoid, cannabindoid, tetrahydrocannabivarin, thcv, transient receptor potential v family member 6, trp, human, channel, closed, trpv6, trp channels, cancer, oncochannel, membrane protein, cnw30, nanodiscs, circularized nanodiscs, nanodisc, vanilloid |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 335710.45 |
Authors | Neuberger, A.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2023-05-02, release date: 2023-08-23) |
Primary citation | Neuberger, A.,Trofimov, Y.A.,Yelshanskaya, M.V.,Khau, J.,Nadezhdin, K.D.,Khosrof, L.S.,Krylov, N.A.,Efremov, R.G.,Sobolevsky, A.I. Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin. Nat Commun, 14:4630-4630, 2023 Cited by PubMed: 37532722DOI: 10.1038/s41467-023-40362-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.79 Å) |
Structure validation
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