8SP7

LINE-1 retrotransposon endonuclease domain complex with tranexamic acid

8SP7 の概要

• エントリーDOI: 10.2210/pdb8sp7/pdb
• 分子名称: LINE-1 retrotransposon endonuclease, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: line-1 retrotransposon, endonuclease, fragment screening, small molecule complex, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27504.68

構造登録者

D'Ordine, A.M.,Jogl, G.,Sedivy, J.M. (登録日: 2023-05-02, 公開日: 2024-05-22)

• 主引用文献: D'Ordine, A.M.,Jogl, G.,Sedivy, J.M.; Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease.; Nat Commun, 15:3883-3883, 2024; PubMed: 38719805; DOI: 10.1038/s41467-024-48066-x

実験手法

X-RAY DIFFRACTION (1.83 Å)