8SOZ

Structure of the complex formed by human interleukin-2 and scFv 602

Summary for 8SOZ

• Entry DOI: 10.2210/pdb8soz/pdb
• Related: 8SOW
• Descriptor: 602 single chain fragment variable, Interleukin-2 (3 entities in total)
• Functional Keywords: complex, antibody, interleukin, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 41289.68

Authors

Gould, J.R.,Leonard, E.K.,Cao, S.D.,Spangler, J.B. (deposition date: 2023-04-30, release date: 2024-09-04)

• Primary citation: Leonard, E.K.,Tomala, J.,Gould, J.R.,Leff, M.I.,Lin, J.X.,Li, P.,Porter, M.J.,Johansen, E.R.,Thompson, L.,Cao, S.D.,Hou, S.,Henclova, T.,Huliciak, M.,Sargunas, P.R.,Fabilane, C.S.,Vanek, O.,Kovar, M.,Schneider, B.,Raimondi, G.,Leonard, W.J.,Spangler, J.B.; Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.; JCI Insight, 2024; PubMed: 39115939; DOI: 10.1172/jci.insight.173469

Experimental method

X-RAY DIFFRACTION (1.64 Å)