8SO3

CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3

8SO3 の概要

• エントリーDOI: 10.2210/pdb8so3/pdb
• EMDBエントリー: 40646
• 分子名称: Lymphocyte activation gene 3 protein, favezelimab Fab heavy chain, favezelimab Fab light chain, ... (4 entities in total)
• 機能のキーワード: lymphocyte activation gene 3 protein, favezelimab-lag3 complex, cryoem, single particle reconstruction., immunosuppressant
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 222224.08

構造登録者

Mishra, A.K.,Shahid, S.,Karade, S.S.,Mariuzza, R.A. (登録日: 2023-04-28, 公開日: 2023-09-06, 最終更新日: 2023-10-18)

• 主引用文献: Mishra, A.K.,Shahid, S.,Karade, S.S.,Agnihotri, P.,Kolesnikov, A.,Hasan, S.S.,Mariuzza, R.A.; CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker.; Structure, 31:1149-, 2023; PubMed: 37619561; DOI: 10.1016/j.str.2023.07.013

実験手法

ELECTRON MICROSCOPY (3.61 Å)