8SMV
GPR161 Gs heterotrimer
Summary for 8SMV
Entry DOI | 10.2210/pdb8smv/pdb |
EMDB information | 40603 |
Descriptor | G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Nanobody 35, ... (6 entities in total) |
Functional Keywords | gpcr, orphan, active, hedgehog, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 154510.47 |
Authors | Hoppe, N.,Manglik, A.,Harrison, S. (deposition date: 2023-04-26, release date: 2024-02-21, Last modification date: 2024-03-20) |
Primary citation | Hoppe, N.,Harrison, S.,Hwang, S.H.,Chen, Z.,Karelina, M.,Deshpande, I.,Suomivuori, C.M.,Palicharla, V.R.,Berry, S.P.,Tschaikner, P.,Regele, D.,Covey, D.F.,Stefan, E.,Marks, D.S.,Reiter, J.,Dror, R.O.,Evers, A.S.,Mukhopadhyay, S.,Manglik, A. GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Biorxiv, 2023 Cited by PubMed: 37292845DOI: 10.1101/2023.05.23.540554 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.74 Å) |
Structure validation
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