8SMC
Cryo-EM structure of LRRK2 bound with type-I inhibitor DNL201
Summary for 8SMC
Entry DOI | 10.2210/pdb8smc/pdb |
EMDB information | 40588 |
Descriptor | non-specific serine/threonine protein kinase, GUANOSINE-5'-DIPHOSPHATE, 2-methyl-2-(3-methyl-4-{[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1H-pyrazol-1-yl)propanenitrile (3 entities in total) |
Functional Keywords | parkinson's disease, kinase, activation, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 137625.99 |
Authors | |
Primary citation | Zhu, H.,Tonelli, F.,Turk, M.,Prescott, A.,Alessi, D.R.,Sun, J. Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science, 382:1404-1411, 2023 Cited by PubMed: 38127736DOI: 10.1126/science.adi9926 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.02 Å) |
Structure validation
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