8SK7

Cryo-EM structure of designed Influenza HA binder, HA_20, bound to Influenza HA (Strain: Iowa43)

8SK7 の概要

• エントリーDOI: 10.2210/pdb8sk7/pdb
• EMDBエントリー: 40557
• 分子名称: Hemagglutinin HA1 chain, Hemagglutinin, HA_20 minibinder (RFdiffusion-designed), ... (6 entities in total)
• 機能のキーワード: flu, influenza, hemagglutinin, ha, iowa43, ha_20, de novo protein, minibinder, binder, designed protein, fusion protein, glycoprotein, de novo protein-viral protein complex, de novo protein/viral protein
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 215503.28

構造登録者

Borst, A.J.,Bennett, N.R. (登録日: 2023-04-18, 公開日: 2023-06-14, 最終更新日: 2023-09-13)

• 主引用文献: Watson, J.L.,Juergens, D.,Bennett, N.R.,Trippe, B.L.,Yim, J.,Eisenach, H.E.,Ahern, W.,Borst, A.J.,Ragotte, R.J.,Milles, L.F.,Wicky, B.I.M.,Hanikel, N.,Pellock, S.J.,Courbet, A.,Sheffler, W.,Wang, J.,Venkatesh, P.,Sappington, I.,Torres, S.V.,Lauko, A.,De Bortoli, V.,Mathieu, E.,Ovchinnikov, S.,Barzilay, R.,Jaakkola, T.S.,DiMaio, F.,Baek, M.,Baker, D.; De novo design of protein structure and function with RFdiffusion.; Nature, 620:1089-1100, 2023; PubMed: 37433327; DOI: 10.1038/s41586-023-06415-8

実験手法

ELECTRON MICROSCOPY (2.93 Å)